Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Primary Cell, Hippocampal Neuron
SUBMITTER: Julian Langer
LAB HEAD: Julian David Langer
PROVIDER: PXD008271 | Pride | 2018-02-16
REPOSITORIES: Pride
Schanzenbächer Christoph T CT Langer Julian D JD Schuman Erin M EM
eLife 20180215
In homeostatic scaling at central synapses, the depth and breadth of cellular mechanisms that detect the offset from the set-point, detect the duration of the offset and implement a cellular response are not well understood. To understand the time-dependent scaling dynamics we treated cultured rat hippocampal cells with either TTX or bicucculline for 2 hr to induce the process of up- or down-scaling, respectively. During the activity manipulation we metabolically labeled newly synthesized protei ...[more]