Analysis of centrosomal protein
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
SUBMITTER: 
Alexander Schmidt
LAB HEAD: Alexander Schmidt
PROVIDER: PXD008272 | Pride | 2018-01-22
REPOSITORIES: Pride
Publications
The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number.
Arquint Christian C Cubizolles Fabien F Morand Agathe A Schmidt Alexander A Nigg Erich A EA
Open biology 20180201 2
Deregulation of centriole duplication has been implicated in cancer and primary microcephaly. Accordingly, it is important to understand how key centriole duplication factors are regulated. E3 ubiquitin ligases have been implicated in controlling the levels of several duplication factors, including PLK4, STIL and SAS-6, but the precise mechanisms ensuring centriole homeostasis remain to be fully understood. Here, we have combined proteomics approaches with the use of MLN4924, a generic inhibitor ...[more]
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