Dynamic changes in proteome and phosphoproteome following glutamate excitotoxicity in cultured primary cortical neurons

ABSTRACT: Excitotoxicity caused by over-stimulation of the ionotropic glutamate receptors is a key neuronal cell death process underpinning brain damage in acute and chronic neurological disorders such as ischaemic stroke, traumatic brain injury, and neurodegenerative diseases. Exactly how neurons die in excitotoxicity still remains unclear and is an important area of research in the field of neuroscience. In this current project we wanted to explore the global changes in proteome and phosphoproteome following glutamate excitotoxicity in cultured primary cortical neurons.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Primary Cell Line Cell, Primary Neuron, Cell Culture

SUBMITTER: Ashfaqul Hoque  

LAB HEAD: Associate Professor Heung-Chin Cheng

PROVIDER: PXD008353 | Pride | 2019-03-07

REPOSITORIES: Pride