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Proteome of EpoR+/+ and EpoR-/- mouse placentas

ABSTRACT: The proteomes of placentas corresponding to EpoR+/+ and EpoR-/- mice were analyzed by label-free LC-MS/MS.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Placenta

SUBMITTER: Alexander Held

LAB HEAD: Ursula Klingmüller

PROVIDER: PXD008368 | Pride | 2022-09-28

REPOSITORIES: Pride

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Erythropoietin-driven dynamic proteome adaptations during erythropoiesis prevent iron overload in the developing embryo.

Chakraborty Sajib S Andrieux Geoffroy G Kastl Philipp P Adlung Lorenz L Altamura Sandro S Boehm Martin E ME Schwarzmüller Luisa E LE Abdullah Yomn Y Wagner Marie-Christine MC Helm Barbara B Gröne Hermann-Josef HJ Lehmann Wolf D WD Boerries Melanie M Busch Hauke H Muckenthaler Martina U MU Schilling Marcel M Klingmüller Ursula U

Cell reports 20220901 12

Erythropoietin (Epo) ensures survival and proliferation of colony-forming unit erythroid (CFU-E) progenitor cells and their differentiation to hemoglobin-containing mature erythrocytes. A lack of Epo-induced responses causes embryonic lethality, but mechanisms regulating the dynamic communication of cellular alterations to the organismal level remain unresolved. By time-resolved transcriptomics and proteomics, we show that Epo induces in CFU-E cells a gradual transition from proliferation signat ...[more]

PMID: 36130519

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