Dataset Information

Systems toxicology assessment of CHTP1.2 [RNE Data]

ABSTRACT: Modified risk tobacco products (MRTPs) have the potential to reduce smoking-related health risks. The Carbon Heated Tobacco Product 1.2 (CHTP1.2) is a potential MRTP that uses a pressed carbon heat source to generate an aerosol by heating tobacco. This study reports the results from the systems toxicology arm of a 90-day rat inhalation study (OECD test guideline 413) to assess the effects of CHTP1.2 aerosol compared with cigarette smoke (CS). Rats were exposed to filtered air (sham), to CHTP1.2 aerosol (at 15, 23 and 50 µg nicotine / L), or to the 3R4F reference cigarette smoke (at 23 µg nicotine / L).

INSTRUMENT(S):

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Nasal Mucosa

SUBMITTER: Bjoern Titz

LAB HEAD: Julia Hoeng

PROVIDER: PXD008424 | Pride | 2018-03-19

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20161111_S150223__RNE_90d_set10_DR_PS_02.raw	Raw
	20161111_S150223__RNE_90d_set10_DR_PS_13.raw	Raw
	20161111_S150223__RNE_90d_set11_DR_PS_03.raw	Raw
	20161111_S150223__RNE_90d_set11_DR_PS_15.raw	Raw
	20161111_S150223__RNE_90d_set12_DR_PS_11.raw	Raw

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Publications

A sandwich electrode for multi-gas analysis: a prototype.

Hahn C E CE Hall E A EA Maynard P P Albery W J WJ

British journal of anaesthesia 19820601 6

A prototype composite electrode consisting of a metallized membrane "outer" cathode, and a conventional "inner" silver disc cathode, both sharing the same electrolyte, is described. Preliminary results indicate that the metallized membrane will act as an oxygen filter, allowing anaesthetic gases such as nitrous oxide, to pass through to the second (inner) cathode, where they may be reduced. Linear relationships exist for oxygen concentration and metallized membrane current; and for nitrous oxide ...[more]

PMID: 7082528

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