Predicting response to chemotherapy in rectal cancer
Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Rectum, Rectum Smooth Muscle Tissue, Epithelial Cell, Epithelium Of Rectum, Fibroblast, Macrophage
DISEASE(S): Rectum Cancer
SUBMITTER: 
Rosalind Jenkins
LAB HEAD: Rosalind Elspeth Jenkins
PROVIDER: PXD008436 | Pride | 2018-03-12
REPOSITORIES: Pride
Publications
Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response.
Bowden D L DL Sutton P A PA Wall M A MA Jithesh P V PV Jenkins R E RE Palmer D H DH Goldring C E CE Parsons J L JL Park B K BK Kitteringham N R NR Vimalachandran D D
Journal of proteomics 20180306
<h4>Background</h4>Neoadjuvant chemoradiotherapy (CRT) is used in locally advanced rectal cancer when tumours threaten the circumferential resection margin, with varying response to treatment. This experimental study aimed to identify significantly differentially expressed proteins between patients responding and not responding to CRT, and to validate any proteins of interest.<h4>Methods</h4>Mass spectrometry (with isobaric tagging for relative quantification) analysis of rectal cancers pre- and ...[more]
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