Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
DISEASE(S): Neurodegenerative Disease
SUBMITTER: Anita Horvatic
LAB HEAD: Silva Katusic Hecimovic
PROVIDER: PXD008438 | Pride | 2018-03-21
REPOSITORIES: Pride
Kosicek Marko M Gudelj Ivan I Horvatic Anita A Jovic Tanja T Vuckovic Frano F Lauc Gordan G Hecimovic Silva S
Molecular & cellular proteomics : MCP 20180124 4
Increasing evidence implicates lysosomal dysfunction in the pathogenesis of neurodegenerative diseases, including the rare inherited lysosomal storage disorders (LSDs) and the most common neurodegenerative diseases, such as Alzheimer's and Parkinson's disease (AD and PD). Although the triggers of the lysosomal impairment may involve the accumulated macromolecules or dysfunction of the lysosomal enzymes, the role of the lysosomal glycocalyx in the lysosomal (dys)function has not been studied. The ...[more]