Proteomics

Dataset Information

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Comparative proteomic analyses of normal human retina, gliotic PVR retina and human Müller glia


ABSTRACT: This study has applied proteomic methodologies to compare protein expression profiles of gliotic and normal human retina as well as established human Müller stem cell lines. It is hoped that this investigation may provide insight into mechanisms of gliosis and also aid studies focusing on endogenous regeneration of the retina following disease or injury

INSTRUMENT(S): Q-Tof Premier

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Retina

DISEASE(S): Proliferative Vitreoretinopathy

SUBMITTER: Karen Eastlake  

LAB HEAD: G. Astrid Limb

PROVIDER: PXD008485 | Pride | 2018-09-06

REPOSITORIES: Pride

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Publications

Comparative proteomic analysis of normal and gliotic PVR retina and contribution of Müller glia to this profile.

Eastlake Karen K   Heywood Wendy E WE   Banerjee Phillip P   Bliss Emily E   Mills Kevin K   Khaw Peng T PT   Charteris David D   Limb G Astrid GA  

Experimental eye research 20180901


Müller glia are responsible for the neural retina regeneration observed in fish and amphibians throughout life. Despite the presence of these cells in the adult human retina, there is no evidence of regeneration occurring in humans following disease or injury. It may be possible that factors present in the degenerated retina could prevent human Müller glia from proliferating and neurally differentiating within the diseased retina. On this basis, investigations into the proteomic profile of these  ...[more]

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