Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA423015
INSTRUMENT(S): LTQ
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Ilya Altukhov
LAB HEAD: John Paul LaCava
PROVIDER: PXD008542 | Pride | 2018-01-17
REPOSITORIES: Pride
Taylor Martin S MS Altukhov Ilya I Molloy Kelly R KR Mita Paolo P Jiang Hua H Adney Emily M EM Wudzinska Aleksandra A Badri Sana S Ischenko Dmitry D Eng George G Burns Kathleen H KH Fenyö David D Chait Brian T BT Alexeev Dmitry D Rout Michael P MP Boeke Jef D JD LaCava John J
eLife 20180108
Long Interspersed Nuclear Element-1 (LINE-1, L1) is a mobile genetic element active in human genomes. L1-encoded ORF1 and ORF2 proteins bind L1 RNAs, forming ribonucleoproteins (RNPs). These RNPs interact with diverse host proteins, some repressive and others required for the L1 lifecycle. Using differential affinity purifications, quantitative mass spectrometry, and next generation RNA sequencing, we have characterized the proteins and nucleic acids associated with distinctive, enzymatically ac ...[more]