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Aberrant Glycosylation Promotes Pancreatic Inflammation

ABSTRACT: CA19-9 is a glycan elevated in human gastrointestinal pathologies, but absent from rodents. We humanized the mouse glycome and found that CA19-9 is not only a correlative biomarker of pancreatic disease, but also plays a causative role in the initiation of pancreatitis. Elevation of CA19-9 results in the activation of EGFR signaling in the normal pancreatic ductal compartment through secretion of Fibulin 3. These signaling changes can be blocked by blocking either CA19-9 or Fibulin 3.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Keith Rivera

LAB HEAD: David Tuveson

PROVIDER: PXD008564 | Pride | 2019-06-06

REPOSITORIES: Pride

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			Action	DRS
	8plex1.dat	Other
	8plex1_Fx1.raw	Raw
	8plex1_Fx2.raw	Raw
	8plex1_Fx3.raw	Raw
	8plex1_Fx4.raw	Raw

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