Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell Of Cervix
SUBMITTER: Jana Zecha
LAB HEAD: Bernhard Kuster
PROVIDER: PXD008579 | Pride | 2018-02-09
REPOSITORIES: Pride
Zecha Jana J Meng Chen C Zolg Daniel Paul DP Samaras Patroklos P Wilhelm Mathias M Kuster Bernhard B
Molecular & cellular proteomics : MCP 20180202 5
The coordination of protein synthesis and degradation regulating protein abundance is a fundamental process in cellular homeostasis. Today, mass spectrometry-based technologies allow determination of endogenous protein turnover on a proteome-wide scale. However, standard dynamic SILAC (Stable Isotope Labeling in Cell Culture) approaches can suffer from missing data across pulse time-points limiting the accuracy of such analysis. This issue is of particular relevance when studying protein stabili ...[more]