Proteomics

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Genomic and Proteomic characterization of Aspergillus niger isolated from the International Space Station

ABSTRACT: Genomic and proteomic characterization of the Aspergillus niger isolate, JSC-093350089, collected from U.S. segment surfaces of the International Space Station (ISS) is reported, along with a comparison to the experimentally established strain ATCC 1015. Whole-genome sequencing of JSC-093350089 revealed enhanced genetic variance when compared to publicly available sequences of A. niger strains. Analysis of the isolate’s proteome revealed significant differences in the molecular phenotype of JSC-093350089, including increased abundance of proteins involved in the A. niger starvation response, oxidative stress resistance, cell wall integrity and modulation, and nutrient acquisition. Together, these data reveal the existence of a distinct strain of A. niger onboard the ISS and provide insight into the molecular phenotype that is selected for by melanized fungal species inhabiting spacecraft environments.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Aspergillus Niger

TISSUE(S): Vegetative Cell (sensu Fungi)

SUBMITTER: Abby Chiang  

LAB HEAD: Markus Kalkum

PROVIDER: PXD008588 | Pride | 2018-08-21

REPOSITORIES: Pride

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Characterization of Aspergillus niger Isolated from the International Space Station.

Romsdahl Jillian J   Blachowicz Adriana A   Chiang Abby J AJ   Singh Nitin N   Stajich Jason E JE   Kalkum Markus M   Venkateswaran Kasthuri K   Wang Clay C C CCC  

mSystems 20180918 5

The initial characterization of the Aspergillus niger isolate JSC-093350089, collected from U.S. segment surfaces of the International Space Station (ISS), is reported, along with a comparison to the extensively studied strain ATCC 1015. Whole-genome sequencing of the ISS isolate enabled its phylogenetic placement within the A. niger/<i>welwitschiae</i>/<i>lacticoffeatus</i> clade and revealed that the genome of JSC-093350089 is within the observed genetic variance of other sequenced A. niger st  ...[more]

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