Proteomics

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Proteomic analysis of Daboia russelli venom samples from Burdwan and Nadia districts of West Bengal, eastern India

ABSTRACT: Russell’s viper (Daboia russelii) (RV), a category I medically important snake as well as a member of the “Big Four”, is responsible for a heavy toll of snake bite mortality and morbidity in Indian sub-continent. Epidemiological studies suggest highest incidence of RV envenomation in eastern India (EI). In this study the RV venom proteomes from Burdwan and Nadia, the two districts of West Bengal, eastern India was deciphered for the first time using tandem mass spectrometry analysis.

INSTRUMENT(S): LTQ Orbitap Discovery

ORGANISM(S): Daboia Russelii

TISSUE(S): Saliva

SUBMITTER: Bhargab Kalita  

LAB HEAD: Dr. Ashis Kumar Mukherjee

PROVIDER: PXD008607 | Pride | 2018-07-16

REPOSITORIES: Pride

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Publications

Proteomic Analysis and Immuno-Profiling of Eastern India Russell's Viper ( Daboia russelii) Venom: Correlation between RVV Composition and Clinical Manifestations Post RV Bite.

Kalita Bhargab B   Patra Aparup A   Das Anjali A   Mukherjee Ashis K AK  

Journal of proteome research 20180710 8

The proteomes of Russell's viper venom (RVV) from Burdwan (RVV B) and Nadia (RVV N), the two districts of West Bengal, eastern India (EI), were investigated by gel-filtration chromatography (GFC) followed by tandem mass spectrometry of tryptic fragments of the fractions. A total of 73 and 69 proteins belonging to 15 snake venom protein families were identified in RVV B and RVV N, respectively, by MS/MS search against Viperidae (taxid 8689) protein entries of the nonredundant NCBI database. The m  ...[more]

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