Proteomics

Dataset Information

49

Expression profiling of HSP90 inhibitor 17-AAG in anti-CD3 and anti-CD28 stimulated T-cells


ABSTRACT: Investigation of expression effects of HSP90 inhibition by 17-AAG of proteins in resting and activated T-cells.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo sapiens  

TISSUE(S): Tissue Not Applicable To Dataset

DISEASE(S): Not Available

SUBMITTER: Maria Faelth Savitski  

LAB HEAD: Marcus Bantscheff

PROVIDER: PXD008627 | Pride | 2018-05-02

REPOSITORIES: Pride

Dataset's files

Source:
altmetric image

Publications


Protein degradation plays important roles in biological processes and is tightly regulated. Further, targeted proteolysis is an emerging research tool and therapeutic strategy. However, proteome-wide technologies to investigate the causes and consequences of protein degradation in biological systems are lacking. We developed "multiplexed proteome dynamics profiling" (mPDP), a mass-spectrometry-based approach combining dynamic-SILAC labeling with isobaric mass tagging for multiplexed analysis of  ...[more]

Similar Datasets

2018-05-02 | PXD008634 | Pride
2018-05-02 | PXD008635 | Pride
2018-04-05 | PXD008633 | Pride
2013-01-10 | E-GEOD-38972 | ArrayExpress
2010-10-11 | E-GEOD-23209 | ArrayExpress
1000-01-01 | S-EPMC1635022 | BioStudies
2010-01-01 | S-EPMC2873497 | BioStudies
2016-01-01 | S-EPMC4821458 | BioStudies
1000-01-01 | S-EPMC5432248 | BioStudies
2014-09-23 | E-GEOD-61284 | ArrayExpress