Human breast cancer cell line and tissue, ISE-affinity proteogenomics

ABSTRACT: Introducing a clinical-practical, alternative splicing activity-based proteogenomic method that identifies, in their oncogenically active states, biomarker genes bearing patient-specific GE or copy-number alterations of prognostic significance. This integrated multi-omics method uses intronic splicing enhancers (ISEs) probes to sort in situ ISE-interacting trans-acting protein factors (trans-interactome) directly from a heterogeneous tumor for subsequent mass spectrometry (MS) characterization.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Breast, Cell Culture, Breast Cancer Cell Line

DISEASE(S): Breast Cancer

SUBMITTER: Li Wang  

LAB HEAD: Xian Chen

PROVIDER: PXD008642 | Pride | 2018-03-20

REPOSITORIES: Pride