Encoding the human serine phosphoproteome in an engineered bacterial system

ABSTRACT: We synthesize a synthetic representation of the human serine phosphoproteome, expressed heterologously as >=31 amino acid phosphopeptides in an engineered strain of E. coli. We confirm that tens of thousands of these phosphopeptides can be successfully expressed and retain important functional characteristics of serine phosphorylation as it occurs in native eukaryotic systems.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human) Escherichia Coli

SUBMITTER: Karl Barber  

LAB HEAD: Jesse Rinehart

PROVIDER: PXD008707 | Pride | 2018-04-17

REPOSITORIES: Pride