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Coordinated regulation of transcription by CcpA and the Staphylococcus aureus two component system HptRS

ABSTRACT: Total cytosolic protein fractions of Staphylococcus aureus strains SA564, SA564-ΔhptRS, SA564-ΔccpA and SA564-ΔhptRS/ccpA were analyzed by LC-MSE . Five biological replicates of each strain, cultivated in TSB and TSB-dex, during the exponential (2h) and post exponential (6h) growth phases (80 samples) were investigated.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Staphylococcus Aureus

TISSUE(S): Whole Body

SUBMITTER: Ryan Grove

LAB HEAD: Greg A. Somerville

PROVIDER: PXD008708 | Pride | 2018-12-19

REPOSITORIES: Pride

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Coordinated regulation of transcription by CcpA and the Staphylococcus aureus two-component system HptRS.

Reed Joseph M JM Olson Sean S Brees Danielle F DF Griffin Caitlin E CE Grove Ryan A RA Davis Paul J PJ Kachman Stephen D SD Adamec Jiri J Somerville Greg A GA

PloS one 20181212 12

The success of Staphylococcus aureus as a pathogen is due in part to its ability to adapt to changing environmental conditions using signal transduction pathways, such as metabolite- responsive regulators and two-component systems. S. aureus has a two-component system encoded by the gene pair sav0224 (hptS) and sav0223 (hptR) that regulate the hexose phosphate transport (uhpT) system in response to extracellular glucose-6-phosphate. Glycolytic intermediates such as glucose-6-phosphate are import ...[more]

PMID: 30540769

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