Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brown Adipose Tissue
SUBMITTER: Danielle Swaney
LAB HEAD: Danielle Swaney
PROVIDER: PXD008798 | Pride | 2021-10-07
REPOSITORIES: Pride
Paulo Esther E Zhang Yun Y Masand Ruchi R Huynh Tony L TL Seo Youngho Y Swaney Danielle L DL Soucheray Margaret M Stevenson Erica E Jimenez-Morales David D Krogan Nevan J NJ Wang Biao B
Cell reports 20210901 12
Cold-induced thermogenesis in endotherms demands adaptive thermogenesis fueled by mitochondrial respiration and Ucp1-mediated uncoupling in multilocular brown adipocytes (BAs). However, dietary regulation of thermogenesis in BAs isn't fully understood. Here, we describe that the deficiency of Leucine-rich pentatricopeptide repeat containing-protein (Lrpprc) in BAs reduces mtDNA-encoded ETC gene expression, causes ETC proteome imbalance, and abolishes the mitochondria-fueled thermogenesis. BA-spe ...[more]