Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Streptococcus Pneumoniae Serotype 2 (strain D39 / Nctc 7466)
TISSUE(S): Cell Culture
SUBMITTER: Xin Yu Miao
LAB HEAD: Xuesong Sun
PROVIDER: PXD008814 | Pride | 2018-08-08
REPOSITORIES: Pride
Frontiers in microbiology 20180720
<i>Streptococcus pneumoniae</i>, a Gram-positive human pathogen, has evolved three main transporters for iron acquisition from the host: PiaABC, PiuABC, and PitABC. Our previous study had shown that the mRNA and protein levels of SPD_1590 are significantly upregulated in the Δ<i>piuA</i>/Δ<i>piaA</i>/Δ<i>pitA</i> triple mutant, suggesting that SPD_1590 might be a novel iron transporter in <i>S. pneumoniae</i>. In the present study, using <i>spd1590</i>-knockout, -complemented, and -overexpressin ...[more]