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Evaluation of preservation quality and viability of FFPE ovarian cancer tissue samples

ABSTRACT: Analysis of 60 FFPE (formalin-fixed, paraffin-embedded) ovarian cancer tissue samples to evaluate preservation quality and viability of global and phosphoproteomic analysis

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Ovary

SUBMITTER: Matthew Monroe

LAB HEAD: Karin Rodland

PROVIDER: PXD008832 | Pride | 2018-10-19

REPOSITORIES: Pride

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Residual tissue repositories as a resource for population-based cancer proteomic studies.

Piehowski Paul D PD Petyuk Vladislav A VA Sontag Ryan L RL Gritsenko Marina A MA Weitz Karl K KK Fillmore Thomas L TL Moon Jamie J Makhlouf Hala H Chuaqui Rodrigo F RF Boja Emily S ES Rodriguez Henry H Lee Jerry S H JSH Smith Richard D RD Carrick Danielle M DM Liu Tao T Rodland Karin D KD

Clinical proteomics 20180803

<h4>Background</h4>Mass spectrometry-based proteomics has become a powerful tool for the identification and quantification of proteins from a wide variety of biological specimens. To date, the majority of studies utilizing tissue samples have been carried out on prospectively collected fresh frozen or optimal cutting temperature (OCT) embedded specimens. However, such specimens are often difficult to obtain, in limited in supply, and clinical information and outcomes on patients are inherently d ...[more]

PMID: 30087585

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