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Multifunctional Activity-Based Protein Profiling of the Developing Lung

ABSTRACT: Data includes proteomics analysis of P450-ABP (2EN, ATW8, ATW12), FP-2, and ATP-ABP labeled mouse lung lysate S9. Lungs from the following developmental stages were used in the study: gestational day 17, post natal days 0, 21, and 42. Also included are global analyses of the same mice lungs.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Lung

SUBMITTER: Matthew Monroe

LAB HEAD: Aaron Wright

PROVIDER: PXD008836 | Pride | 2018-10-22

REPOSITORIES: Pride

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Multifunctional Activity-Based Protein Profiling of the Developing Lung.

Stoddard Ethan G EG Volk Regan F RF Carson James P JP Ljungberg Cecilia M CM Murphree Taylor A TA Smith Jordan N JN Sadler Natalie C NC Shukla Anil K AK Ansong Charles C Wright Aaron T AT

Journal of proteome research 20180718 8

Lung diseases and disorders are a leading cause of death among infants. Many of these diseases and disorders are caused by premature birth and underdeveloped lungs. In addition to developmentally related disorders, the lungs are exposed to a variety of environmental contaminants and xenobiotics upon birth that can cause breathing issues and are progenitors of cancer. In order to gain a deeper understanding of the developing lung, we applied an activity-based chemoproteomics approach for the func ...[more]

PMID: 29972024

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