BRAF and IKKα involvement in DNA Damage Response

ABSTRACT: BRAF and IKKα are damage-responsive kinases required for 53BP1 and RIF1 co-recruitment to sites of DNA breaks and for timely resolution of DNA lesions. This provides a novel therapeutic opportunity based on combining BRAF or IKKα inhibitors with therapeutic agents that induce DNA damage

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

DISEASE(S): Colon Cancer

SUBMITTER: Eva Borràs  

LAB HEAD: Eduard Sabido

PROVIDER: PXD008932 | Pride | 2019-11-14

REPOSITORIES: Pride