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Mouse embryonic stem cell phosphoproteome

ABSTRACT: Erk-driven differentiation of mouse embryonic stem cells

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Embryo, Embryonic Stem Cell

SUBMITTER: Jesper Olsen

LAB HEAD: Jesper Velgaard Olsen

PROVIDER: PXD008964 | Pride | 2019-10-22

REPOSITORIES: Pride

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Dynamic lineage priming is driven via direct enhancer regulation by ERK.

Hamilton William B WB Mosesson Yaron Y Monteiro Rita S RS Emdal Kristina B KB Knudsen Teresa E TE Francavilla Chiara C Barkai Naama N Olsen Jesper V JV Brickman Joshua M JM

Nature 20191106 7782

Central to understanding cellular behaviour in multi-cellular organisms is the question of how a cell exits one transcriptional state to adopt and eventually become committed to another. Fibroblast growth factor-extracellular signal-regulated kinase (FGF -ERK) signalling drives differentiation of mouse embryonic stem cells (ES cells) and pre-implantation embryos towards primitive endoderm, and inhibiting ERK supports ES cell self-renewal<sup>1</sup>. Paracrine FGF-ERK signalling induces heteroge ...[more]

PMID: 31695196

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