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Human Th17 Cell differentiation

ABSTRACT: The early stages of human Th17 Cell differentiation were studied using label free proteomics to compare Th17 polarized CD4+ human T cells at 24 h and 72 h with activated cells (72 and 24 h) and Thp cells.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): T Cell, Blood

SUBMITTER: Robert Moulder

LAB HEAD: Professor Riitta Lahesmaa

PROVIDER: PXD008973 | Pride | 2019-01-28

REPOSITORIES: Pride

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Quantitative Proteomics Reveals the Dynamic Protein Landscape during Initiation of Human Th17 Cell Polarization.

Tripathi Subhash K SK Välikangas Tommi T Shetty Ankitha A Khan Mohd Moin MM Moulder Robert R Bhosale Santosh D SD Komsi Elina E Salo Verna V De Albuquerque Rafael Sales RS Rasool Omid O Galande Sanjeev S Elo Laura L LL Lahesmaa Riitta R

iScience 20181226

Th17 cells contribute to the pathogenesis of inflammatory and autoimmune diseases and cancer. To reveal the Th17 cell-specific proteomic signature regulating Th17 cell differentiation and function in humans, we used a label-free mass spectrometry-based approach. Furthermore, a comprehensive analysis of the proteome and transcriptome of cells during human Th17 differentiation revealed a high degree of overlap between the datasets. However, when compared with corresponding published mouse data, we ...[more]

PMID: 30641411

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2020-03-25 | PXD016633 | Pride

Arabidopsis rosettes proteome in response to LCO and Th17 under salt stress- LC-MS/MS

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Chemical Inhibition of the RORγt-dependent Transcriptional Network in Th17 cells [RNA-Seq 2]

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Jarid2, a Polycomb member and target of miR-155, regulates the fates of Th17 and Treg cells

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