Identification of changes in the LNZ308 HLA immunopeptidome after virotherapy, irradiation and chemotherapy

ABSTRACT: Glioblastoma is an aggressive incurable primary malignant brain tumor. Measles virus (MeV) therapy is a promising upcoming treatment strategy with proven preclinical efficacy and clinical safety. Using RNA Sequencing and immunopeptidome analyses, we aimed at identifying a synergistic combination regimen of MeV with conventional therapeutic strategies for glioblastoma patients, i.e. radiotherapy and temozolomide or lomustine, and to understand the underlying molecular mechanism.

OTHER RELATED OMICS DATASETS IN: GSE111247

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

DISEASE(S): Brain Glioblastoma Multiforme,Brain Cancer

SUBMITTER: Michael Ghosh  

LAB HEAD: Prof. Dr. Stefan Stevanović

PROVIDER: PXD008984 | Pride | 2018-02-19

REPOSITORIES: Pride