Dataset Information

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

ABSTRACT: Wild-type or TRAF2 mutated melanoma cells were treated with TNFalpha or co-cultured with activated T-cells for various short incubations (5min to 6 hours). Cells were harvested and analyzed using mass spectrometry for treatment induced changes at the proteome and phosphoproteome level.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Kelly Stecker

LAB HEAD: Kelly Stecker

PROVIDER: PXD008995 | Pride | 2025-02-14

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	20170825_OR15_Ag2_Steck001_SA_TRAF2_BR1_proteome_F1.raw	Raw
	20170825_OR15_Ag2_Steck001_SA_TRAF2_BR1_proteome_F10.raw	Raw
	20170825_OR15_Ag2_Steck001_SA_TRAF2_BR1_proteome_F11.raw	Raw
	20170825_OR15_Ag2_Steck001_SA_TRAF2_BR1_proteome_F12.raw	Raw
	20170825_OR15_Ag2_Steck001_SA_TRAF2_BR1_proteome_F13.raw	Raw

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Publications

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold.

Vredevoogd David W DW Kuilman Thomas T Ligtenberg Maarten A MA Boshuizen Julia J Stecker Kelly E KE de Bruijn Beaunelle B Krijgsman Oscar O Huang Xinyao X Kenski Juliana C N JCN Lacroix Ruben R Mezzadra Riccardo R Gomez-Eerland Raquel R Yildiz Mete M Dagidir Ilknur I Apriamashvili Georgi G Zandhuis Nordin N van der Noort Vincent V Visser Nils L NL Blank Christian U CU Altelaar Maarten M Schumacher Ton N TN Peeper Daniel S DS

Cell 20190711 3

New opportunities are needed to increase immune checkpoint blockade (ICB) benefit. Whereas the interferon (IFN)γ pathway harbors both ICB resistance factors and therapeutic opportunities, this has not been systematically investigated for IFNγ-independent signaling routes. A genome-wide CRISPR/Cas9 screen to sensitize IFNγ receptor-deficient tumor cells to CD8 T cell elimination uncovered several hits mapping to the tumor necrosis factor (TNF) pathway. Clinically, we show that TNF antitumor activ ...[more]

PMID: 31303383

Dataset Information

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

Dataset's files

Publications

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold.

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