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Identification of the proteins secreted by normal and cirrhotic LSECs

ABSTRACT: Normal and cirrhotic LSECs can influence hepatic stellate cells (HSCs) differently. This project aims to determine the set of proteins secreted by LSECs from healthy and cirrhotic livers, and identify the protein(s) that promote HSC activation.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver, Cell Culture, Endothelial Cell

DISEASE(S): Liver Cirrhosis

SUBMITTER: Ana Maretti-Mira

LAB HEAD: Laurie D. DeLeve

PROVIDER: PXD009010 | Pride | 2018-11-06

REPOSITORIES: Pride

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Incomplete Differentiation of Engrafted Bone Marrow Endothelial Progenitor Cells Initiates Hepatic Fibrosis in the Rat.

Maretti-Mira Ana C AC Wang Xiangdong X Wang Lei L DeLeve Laurie D LD

Hepatology (Baltimore, Md.) 20190207 3

Normal liver sinusoidal endothelial cells (LSECs) promote quiescence of hepatic stellate cells (HSCs). Prior to fibrosis, LSECs undergo capillarization, which is permissive for HSC activation, the proximate event in hepatic fibrosis. The aims of this study were to elucidate the nature of and mechanisms leading to capillarization and to determine how LSECs promote HSC quiescence and why "capillarized LSECs" lose control of HSC activation. The contribution of bone marrow (BM) endothelial progenito ...[more]

PMID: 30141211

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