Macrophage proteome in response to Mycobacterium tuberculosis infection

ABSTRACT: This study investigates the proteomic alterations in human monocytic cell line (THP1) subsequent to infection with different strains of mycobacterium tuberculosis (H37Ra, H37Rv, BND433 and JAL2287) using the SWATH-MS strategy. THP1 proteome was analysed after 6, 18, 30 and 42 hours of infection with each strains and compared to that of uninfected cells. Our findings reveal temporal regulation of host response subsequent to Mtb infection.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human) Mycobacterium Tuberculosis

TISSUE(S): Cell Culture, Macrophage

SUBMITTER: Ajay Kumar  

LAB HEAD: Ajay Kumar

PROVIDER: PXD009046 | Pride | 2020-09-23

REPOSITORIES: Pride