Proteomics

Dataset Information

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Fasting differentially alters the hypothalamic proteome of chickens from lines selected for low or high body weight


ABSTRACT: The hypothalamic proteomes of low and high body weight selected chicks were compared at both a fed and fasted state.

INSTRUMENT(S): Synapt G2-S HDMS

ORGANISM(S): Gallus gallus  

TISSUE(S): Hypothalamus

DISEASE(S): Not Available

SUBMITTER: Keith Ray  

LAB HEAD: Elizabeth Ruth Gilbert

PROVIDER: PXD009086 | Pride | 2019-07-12

REPOSITORIES: pride

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Publications

Fasting differentially alters the hypothalamic proteome of chickens from lines with the propensity to be anorexic or obese.

Liu Lingbin L   Yi Jiaqing J   Ray W Keith WK   Vu Lucas T LT   Helm Richard F RF   Siegel Paul B PB   Cline Mark A MA   Gilbert Elizabeth R ER  

Nutrition & diabetes 20190401 1


BACKGROUND:The hypothalamus is the ultimate modulator of appetite and energy balance and therefore sensitive to changes in nutritional state. Chicks from lines selected for low (LWS) and high (HWS) body weight are hypophagic and compulsive eaters, respectively, and differ in their propensity to become obese and in their hypothalamic mRNA response to fasting. METHODS:As fasting-induced changes in hypothalamic proteins are unknown, we investigated the hypothalamic proteomes of 5-day old LWS and HW  ...[more]

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