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Integrated FTIR imaging and proteomics for identification of a candidate histochemical biomarker in bladder cancer

ABSTRACT: A quantitative label-free proteome analysis of cystitis and high-grade bladder cancer tissue priorly annotated and isolated via FTIR-guided lasermicrodissection.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Urinary Bladder, Bladder Urothelial Cell

DISEASE(S): Bladder Transitional Cell Carcinoma

SUBMITTER: Thilo Bracht

LAB HEAD: Barbara Sitek

PROVIDER: PXD009203 | Pride | 2019-08-13

REPOSITORIES: Pride

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Integrated Fourier Transform Infrared Imaging and Proteomics for Identification of a Candidate Histochemical Biomarker in Bladder Cancer.

Witzke Kathrin E KE Großerueschkamp Frederik F Jütte Hendrik H Horn Melanie M Roghmann Florian F von Landenberg Nicolas N Bracht Thilo T Kallenbach-Thieltges Angela A Käfferlein Heiko H Brüning Thomas T Schork Karin K Eisenacher Martin M Marcus Katrin K Noldus Joachim J Tannapfel Andrea A Sitek Barbara B Gerwert Klaus K

The American journal of pathology 20190212 3

Histopathological differentiation between severe urocystitis with reactive urothelial atypia and carcinoma in situ (CIS) can be difficult, particularly after a treatment that deliberately induces an inflammatory reaction, such as intravesical instillation of Bacillus Calmette-Guèrin. However, precise grading in bladder cancer is critical for therapeutic decision making and thus requires reliable immunohistochemical biomarkers. Herein, an exemplary potential biomarker in bladder cancer was identi ...[more]

PMID: 30770125

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