Dataset Information

Comparative hippocampal synaptic proteomes of rodents and primates: differences in neuroplasticity-related proteins

ABSTRACT: Key to the human brain’s unique capacities are a myriad of neural cell types, specialized molecular expression signatures, and complex patterns of neuronal connectivity. Neurons in the human brain communicate via well over a quadrillion synapses. Their specific contribution might be key to the dynamic activity patterns that underlie primate-specific cognitive function. Recently, functional differences were described in transmission capabilities of human and rat synapses. To test whether unique expression signatures of synaptic proteins are at the basis of this, we performed a quantitative analysis of the hippocampal synaptic proteome of four mammalian species, two primates, human and marmoset, and two rodents, rat and mouse. Abundance differences down to 1.15-fold at an FDR-corrected p-value of 0.005 were reliably detected using SWATH mass spectrometry. The high measurement accuracy of SWATH allowed the detection of a large group of differentially expressed proteins between individual species and rodent versus primate. Differentially expressed proteins between rodent and primate were found highly enriched for plasticity-related proteins.

INSTRUMENT(S): Orbitrap Fusion Lumos, TripleTOF 5600

ORGANISM(S): Rattus Norvegicus (rat) Marmosets Homo Sapiens (human) Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Frank Koopmans

LAB HEAD: Ka Wan Li

PROVIDER: PXD009251 | Pride | 2018-10-22

REPOSITORIES: Pride

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Publications

Comparative Hippocampal Synaptic Proteomes of Rodents and Primates: Differences in Neuroplasticity-Related Proteins.

Koopmans Frank F Pandya Nikhil J NJ Franke Sigrid K SK Phillippens Ingrid H C M H IHCMH Paliukhovich Iryna I Li Ka Wan KW Smit August B AB

Frontiers in molecular neuroscience 20181002

Key to the human brain's unique capacities are a myriad of neural cell types, specialized molecular expression signatures, and complex patterns of neuronal connectivity. Neurons in the human brain communicate via well over a quadrillion synapses. Their specific contribution might be key to the dynamic activity patterns that underlie primate-specific cognitive function. Recently, functional differences were described in transmission capabilities of human and rat synapses. To test whether unique e ...[more]

PMID: 30333727

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Dataset Information

Comparative hippocampal synaptic proteomes of rodents and primates: differences in neuroplasticity-related proteins

Publications

Comparative Hippocampal Synaptic Proteomes of Rodents and Primates: Differences in Neuroplasticity-Related Proteins.

Similar Datasets

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