Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 6600
ORGANISM(S): Caenorhabditis Elegans
TISSUE(S): Whole Body
SUBMITTER: Evan Williams
LAB HEAD: Ruedi Aebersold
PROVIDER: PXD009256 | Pride | 2020-04-03
REPOSITORIES: Pride
Liu Yasmine J YJ McIntyre Rebecca L RL Janssens Georges E GE Williams Evan G EG Lan Jiayi J van Weeghel Michel M Schomakers Bauke B van der Veen Henk H van der Wel Nicole N NN Yao Pallas P Mair William B WB Aebersold Ruedi R MacInnes Alyson W AW Houtkooper Riekelt H RH
The Journal of cell biology 20200601 6
Mitochondrial form and function are closely interlinked in homeostasis and aging. Inhibiting mitochondrial translation is known to increase lifespan in C. elegans, and is accompanied by a fragmented mitochondrial network. However, whether this link between mitochondrial translation and morphology is causal in longevity remains uncharacterized. Here, we show in C. elegans that disrupting mitochondrial network homeostasis by blocking fission or fusion synergizes with reduced mitochondrial translat ...[more]