DNA repair proximity landscape analysis reveals shieldin as a key regulator of NHEJ-dependent processes
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell
SUBMITTER: 
Rajat Gupta
LAB HEAD: Chunaram Choudhary
PROVIDER: PXD009284 | Pride | 2018-04-13
REPOSITORIES: Pride
Publications
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.
Gupta Rajat R Somyajit Kumar K Narita Takeo T Maskey Elina E Stanlie Andre A Kremer Magdalena M Typas Dimitris D Lammers Michael M Mailand Niels N Nussenzweig Andre A Lukas Jiri J Choudhary Chunaram C
Cell 20180412 4
Repair of damaged DNA is essential for maintaining genome integrity and for preventing genome-instability-associated diseases, such as cancer. By combining proximity labeling with quantitative mass spectrometry, we generated high-resolution interaction neighborhood maps of the endogenously expressed DNA repair factors 53BP1, BRCA1, and MDC1. Our spatially resolved interaction maps reveal rich network intricacies, identify shared and bait-specific interaction modules, and implicate previously con ...[more]
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