Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA433925
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): T Cell, Jurkat Cell
DISEASE(S): Acute Leukemia
SUBMITTER: Alexey Stukalov
LAB HEAD: Florian Grebien
PROVIDER: PXD009338 | Pride | 2018-05-25
REPOSITORIES: Pride
Skucha Anna A Ebner Jessica J Schmöllerl Johannes J Roth Mareike M Eder Thomas T César-Razquin Adrián A Stukalov Alexey A Vittori Sarah S Muhar Matthias M Lu Bin B Aichinger Martin M Jude Julian J Müller André C AC Győrffy Balázs B Vakoc Christopher R CR Valent Peter P Bennett Keiryn L KL Zuber Johannes J Superti-Furga Giulio G Grebien Florian F
Nature communications 20180518 1
MLL-fusions represent a large group of leukemia drivers, whose diversity originates from the vast molecular heterogeneity of C-terminal fusion partners of MLL. While studies of selected MLL-fusions have revealed critical molecular pathways, unifying mechanisms across all MLL-fusions remain poorly understood. We present the first comprehensive survey of protein-protein interactions of seven distantly related MLL-fusion proteins. Functional investigation of 128 conserved MLL-fusion-interactors ide ...[more]