Ontology highlight
ABSTRACT:
INSTRUMENT(S): ultraflex
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
DISEASE(S): Alzheimer's Disease
SUBMITTER: Allan Stensballe
LAB HEAD: Allan Stensballe
PROVIDER: PXD009353 | Pride | 2021-03-25
REPOSITORIES: Pride
Bastrup Joakim J Birkelund Svend S Asuni Ayodeji A AA Volbracht Christiane C Stensballe Allan A
Rapid communications in mass spectrometry : RCM 20191101 22
<h4>Rationale</h4>The molecular complexity of tissue features several signal-suppression effects which reduce the ionization of analytes significantly and thereby weakens the quality of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) imaging (MALDI imaging). We report a novel approach in MALDI imaging by reducing signal-suppression effects for the analysis of beta-amyloid (Aβ) plaques, one pathological hallmark of Alzheimer's disease (AD).<h4>Methods</h4>We analyzed Aβ ...[more]