Dataset Information

The platelet releasate (PR) in human pregnancy

ABSTRACT: Healthy pregnancy is characterized by an increase in platelet activation and a decrease in the number of circulating platelets with gestation. Despite this recognised importance, proteomic studies investigating platelets in healthy pregnancy have not been performed. As platelet cargo can be altered in different conditions, we hypothesised that platelets may store a relevant and bespoke collection of molecules during pregnancy. To examine this, we performed comparative label-free quantitative proteomic profiling of platelet releasates from healthy pregnant and non-pregnant women using a tandem mass spectrometry approach. Of the 723 proteins identified, 69 PR proteins were found to be differentially released from platelets in pregnancy, including proteins only expressed during pregnancy such as pregnancy-specific glycoproteins and human placental lactogen.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Platelet, Platelet

SUBMITTER: Paulina Szklanna

LAB HEAD: Patricia B. Maguire

PROVIDER: PXD009361 | Pride | 2020-06-05

REPOSITORIES: Pride

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Publications

The Platelet Releasate is Altered in Human Pregnancy.

Szklanna Paulina B PB Parsons Martin E ME Wynne Kieran K O'Connor Hugh H Egan Karl K Allen Seamus S Ní Áinle Fionnuala F Maguire Patricia B PB

Proteomics. Clinical applications 20181029 3

<h4>Purpose</h4>Healthy pregnancy is characterized by an increase in platelet activation and a decrease in the number of circulating platelets with gestation. Despite this recognized importance, proteomic studies investigating platelets in healthy pregnancy have not been performed. As platelet cargo can be altered in different conditions, it is hypothesized that platelets may store a relevant and bespoke collection of molecules during pregnancy.<h4>Experimental design</h4>Comparative label-free ...[more]

PMID: 30318839

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Dataset Information

The platelet releasate (PR) in human pregnancy

Publications

The Platelet Releasate is Altered in Human Pregnancy.

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