Browse
Submit Data
Databases
API
Help

Dataset Information

127 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Comparison of proteins in secretory/excretory products of the salmon louse, Lepeophtheirus salmonis.

ABSTRACT: Comparative Proteomics of the Secretory/Excretory products (SEPs) of 2 life stages L.salmonisusing LC-ESI-MS/MS.

INSTRUMENT(S): Bruker Daltonics amaZon series

ORGANISM(S): Lepeophtheirus Salmonis

TISSUE(S): Excretion, Secretion

SUBMITTER: Kevin Mclean

LAB HEAD: Neil Inglis

PROVIDER: PXD009391 | Pride | 2018-10-19

REPOSITORIES: Pride

ACCESS DATA

Json Xml

Publications

Characterisation of proteins in excretory/secretory products collected from salmon lice, Lepeophtheirus salmonis.

Hamilton Scott S McLean Kevin K Monaghan Sean J SJ McNair Carol C Inglis Neil F NF McDonald Hazel H Adams Sandra S Richards Randolph R Roy William W Smith Patrick P Bron James J Nisbet Alasdair J AJ Knox David D

Parasites & vectors 20180511 1

<h4>Background</h4>The salmon louse, Lepeophtheirus salmonis, is an ectoparasitic copepod which feeds on the mucus, skin and blood of salmonid fish species. The parasite can persist on the surface of the fish without any effective control being exerted by the host immune system. Other ectoparasitic invertebrates produce compounds in their saliva, excretions and/or secretions which modulate the host immune responses allowing them to remain on or in the host during development. Similarly, compound ...[more]

PMID: 29751843

Similar Datasets

Cysteamine inhibits glycine utilisation and disrupts virulence in Pseudomonas aeruginosa

Project description:Pseudomonas aeruginosa is a major opportunistic human pathogen which employs a myriad of virulence factors. In people with cystic fibrosis (CF) P. aeruginosa frequently colonises the lungs and becomes a chronic infection that evolves to become less virulent over time, but often adapts to favour persistence in the host with alginate-producing mucoid, slow-growing, and antibiotic resistant phenotypes emerging. Cysteamine is an endogenous aminothiol which has been shown to prevent biofilm formation, reduce phenazine production, and potentiate antibiotic activity against P. aeruginosa, and has been investigated in clinical trials as an adjunct therapy for pulmonary exacerbations of CF. Here we demonstrate (for the first time in a prokaryote) that cysteamine prevents glycine utilisation by P. aeruginosa in common with reported activity blocking the glycine cleavage system in human cells. Despite the inhibition of glycine metabolism, cysteamine inhibits hydrogen cyanide (HCN) production by P. aeruginosa, implicating interference in the regulation of virulence. Cysteamine impaired chemotaxis and reductions in pyocyanin and exopolysaccharide production in cysteamine-treated P. aeruginosa and reduced toxicity of secreted factors in a Galleria mellonella model. Thus, cysteamine has additional potent anti-virulence properties targeting P. aeruginosa, further supporting its therapeutic potential in CF and other infections.

2021-08-19 | PXD027156 | Pride

Multi-omics analysis reveals concerted molecular responses to heat stress in a “red tide” dinoflagellate

Project description:Harmful algal blooms are induced largely by nutrient enrichment common in warm waters. An increasingly frequent phenomenon is the “red tide”: blooms of dinoflagellate microalgae that accumulate toxins lethal to other organisms in high doses. Here, we present the de novo assembled genome (~4.75 Gbp) of Prorocentrum cordatum, a globally abundant, bloom-forming dinoflagellate, and the associated transcriptome, proteome, and metabolome data from axenic cultures to elucidate the microalgal molecular responses to heat stress. We discovered, in a high-G+C genome with long introns and extensive genetic duplication, a complementary mechanism between RNA editing and exon usage that regulates dynamic expression and functional diversity of genes and proteins, and metabolic profiles that reflect reduced capacities in photosynthesis, central metabolism, and protein synthesis. These results based on multi-omics evidence demonstrate the genomic hallmark of a bloom-forming dinoflagellate, and how the complex gene structures combined with multi-level transcriptional regulation underpin concerted heat-stress responses.

2023-10-18 | PXD046193 | Pride

Proteome compendium of the Antarctic krill (Euphausia superba) - Muscle

Project description:The Antarctic krill provides central ecosystems services to the Southern Ocean grazing on autotroph and heterotoph diet and constituting the dominant food source for higher trophic levels. Moreover, E. superba's extensive equipment with biomacromolecule hydrolysing enzymes represents a largely untapped resource for applied purposes. The proteome compendium of krill provides a valuable basis for future studies on krill biology (e.g., metabolism, development, migration behaviour), for krill's contribution to organic matter turnover in the Southern Ocean, as well as for multilevel biotechnological prospecting.

2022-09-28 | PXD033601 | Pride

Proteome compendium of the Antarctic krill (Euphausia superba) - Whole body

2022-09-28 | PXD033602 | Pride

Proteome compendium of the Antarctic krill (Euphausia superba) - Telson

2022-09-28 | PXD033775 | Pride

Proteome compendium of the Antarctic krill (Euphausia superba) - Head

2022-09-28 | PXD033597 | Pride

Proteome compendium of the Antarctic krill (Euphausia superba) - Carapace

2022-09-28 | PXD033594 | Pride

Identification of proteins from the secretory / excretory products (SEPs) of the branchiuran ectoparasite Argulus foliaceus

Project description:A. foliaceus secretory / excretory products (SEPs) were collected from 560 active adult parasites and identified and characterised using LC-ESI-MS/MS analysis.

2020-02-28 | PXD016226 | Pride

Mouse spleen LC-MSMS from C57BL/6J WT, CD38-deficient and B6.C-H2bm12/KHEg (bm12) mice in cGVHD lupus-like model

Project description:Proteins from post-nuclear cell lysates from C57BL/6J WT, CD38-deficient and B6.C-H2bm12/KHEg (bm12) recipient mice at 2 weeks after the adoptive transfer of co-isogenic spleen cells were identified using a proteomic approach. The relative abundances of the proteins identified were calculated using emPAIs scores.

2021-10-11 | PXD026947 | Pride

Proteomics Analysis of Bacterial Chondronecrosis with Osteomyelitis in Broiler Chickens

Project description:Proteomic analysis was performed on the proximal tibia head from healhty and BCO-affected broiler (meat-type) chickens using Bruker Daltonics amaZon series Mass Spectrometer. This analysis was undertaken to identify key protein signature involved in BCO, a common cause of lameness.

2023-05-10 | PXD029085 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data