Proteome analysis of brain microvessels from htra1 KO mice
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Microvessel
SUBMITTER: 
Stephan Mueller
LAB HEAD: Christof Haffner
PROVIDER: PXD009411 | Pride | 2018-08-03
REPOSITORIES: Pride
Publications
CADASIL brain vessels show a HTRA1 loss-of-function profile.
Zellner Andreas A Scharrer Eva E Arzberger Thomas T Oka Chio C Domenga-Denier Valérie V Joutel Anne A Lichtenthaler Stefan F SF Müller Stephan A SA Dichgans Martin M Haffner Christof C
Acta neuropathologica 20180503 1
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and a phenotypically similar recessive condition (CARASIL) have emerged as important genetic model diseases for studying the molecular pathomechanisms of cerebral small vessel disease (SVD). CADASIL, the most frequent and intensely explored monogenic SVD, is characterized by a severe pathology in the cerebral vasculature including the mutation-induced aggregation of the Notch3 extracellular domai ...[more]
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