Mouse CDC73 AP-MS in AML - PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia

ABSTRACT: Here we performed AP-MS experiments to find novel binding partners of CDC73 in mouse M1 AML cells. We also utilized a CDC73 mutant that does not support AML cell growth to determine functional consequences of gainin/ losing protein-protein interactions on mutation of this protein.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Suspension Culture, Blood Cell, Blood

DISEASE(S): Acute Leukemia

SUBMITTER: James Ropa  

LAB HEAD: Andrew G Muntean

PROVIDER: PXD009439 | Pride | 2018-05-22

REPOSITORIES: Pride