Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap XL, Orbitrap Fusion, Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain, Lung, Hela Cell
SUBMITTER: Jonas Drechsel
LAB HEAD: Stephan A Sieber
PROVIDER: PXD009444 | Pride | 2018-07-17
REPOSITORIES: Pride
ACS chemical biology 20180719 8
Reactive oxygen species (ROS) play an important role in the onset of Parkinson's disease (PD), and deciphering protective mechanisms is a major goal for therapeutic development. Here, DJ-1 (PARK7) gained major attention when a conserved cysteine residue with a putative role in oxidative stress sensing/protection was linked to PD. Inspired by previous studies with a bacterial homologue of DJ-1, several amino-epoxycylcohexenones were screened for enzyme inhibition, and a chemical probe with specif ...[more]