Spop restrains inflammation-induced emergency hematopoiesis by targeting MyD88

ABSTRACT: Innate immune cells, and myeloid lineage cells in particular, constitute the first line ofdefense for the containment of invading pathogens. To meet the augmented demand of myeloidcells in response to systemic infections, inflammatory signals trigger a rapid transcriptional response inhematopoietic stem and progenitor cells (HSPCs), promoting their proliferation and preferential differentiation towards the granulocytic lineage

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Bone Marrow

DISEASE(S): Acute Leukemia

SUBMITTER: Anita Saraf  

LAB HEAD: Anita Saraf

PROVIDER: PXD009469 | Pride | 2019-07-12

REPOSITORIES: Pride