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Rat kidney LC-MS - Exploring the Therapeutic Mechanism of Desmodium styracifolium on Oxalate Crystal-Induced Kidney Injuries Using Comprehensive Approaches Based on Proteomics and Network Pharmacology

ABSTRACT: Oxalate-induced kidney injury rat model were established.The differentially expressed proteins in the kidneys between the oxalate and control groups were explored.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Rattus Rattus (black Rat)

TISSUE(S): Kidney

DISEASE(S): Nephrolithiasis

SUBMITTER: Jiebin Hou

LAB HEAD: Xin Dong

PROVIDER: PXD009496 | Pride | 2018-10-19

REPOSITORIES: Pride

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Exploring the Therapeutic Mechanism of Desmodium styracifolium on Oxalate Crystal-Induced Kidney Injuries Using Comprehensive Approaches Based on Proteomics and Network Pharmacology.

Hou Jiebin J Chen Wei W Lu Hongtao H Zhao Hongxia H Gao Songyan S Liu Wenrui W Dong Xin X Guo Zhiyong Z

Frontiers in pharmacology 20180613

Purpose: As a Chinese medicinal herb, Desmodium styracifolium (Osb.) Merr (DS) has been applied clinically to alleviate crystal-induced kidney injuries, but its effective components and their specific mechanisms still need further exploration. This research first combined the methods of network pharmacology and proteomics to explore the therapeutic protein targets of DS on oxalate crystal-induced kidney injuries to provide a reference for relevant clinical use. Methods: Oxal ...[more]

PMID: 29950996

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