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Identification of Acinetobacter baumannii AB307-0294 type VI secretion system secreted proteins

ABSTRACT: In order to identify secreted proteins associated with the type VI secretion system (T6SS), the secretome of a wild-type A. baumannii AB307 0294 T6SS active strain was compared to the secretome of a T6SS inactive mutant strain, A. baumannii AB307-0294ΔtssM.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Acinetobacter Baumannii

SUBMITTER: Ralf Schittenhelm

LAB HEAD: John Boyce

PROVIDER: PXD009528 | Pride | 2018-05-25

REPOSITORIES: Pride

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Identification of Novel Acinetobacter baumannii Type VI Secretion System Antibacterial Effector and Immunity Pairs.

Fitzsimons Timothy C TC Lewis Jessica M JM Wright Amy A Kleifeld Oded O Schittenhelm Ralf B RB Powell David D Harper Marina M Boyce John D JD

Infection and immunity 20180723 8

The type VI secretion system (T6SS) is a macromolecular machine that delivers protein effectors into host cells and/or competing bacteria. The effectors may be delivered as noncovalently bound cargo of T6SS needle proteins (VgrG/Hcp/PAAR) or as C-terminal extensions of these proteins. Many Acinetobacter baumannii strains produce a T6SS, but little is known about the specific effectors or how they are delivered. In this study, we show that A. baumannii AB307-0294 encodes three vg ...[more]

PMID: 29735524

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