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Identification of candidate biomarkers for the early detection of radiation induced cutaneous erythema by quantitative proteomic analysis using a Data Independent Mass Spectrometry

ABSTRACT: This work is an effort to identify a set of changes in serum protein expression levels during the early post-irradiation phase of patients treated with radiotherapy because of brain cancer. We performed a comparative proteomic analysis based on a DIA-MS approach.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

DISEASE(S): Brain Cancer

SUBMITTER: Giovanni Chiappetta

LAB HEAD: Joelle Vinh

PROVIDER: PXD009587 | Pride | 2019-07-19

REPOSITORIES: Pride

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			Action	DRS
	Amira_IEF.pep.xml	Pepxml
	HF170414_0464_i_gch.raw	Raw
	HF170414_0465_i_gch.raw	Raw
	HF170414_0467_i_gch.raw	Raw
	HF170414_0468_i_gch.raw	Raw

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Publications

Investigation of serum proteome homeostasis during radiation therapy by a quantitative proteomics approach.

Ouerhani Amira A Chiappetta Giovanni G Souiai Oussema O Mahjoubi Halima H Vinh Joelle J

Bioscience reports 20190729 7

The purpose of the present study is to analyze the serum proteome of patients receiving Radiation Therapy (RT) at different stages of their treatment to discovery candidate biomarkers of the radiation-induced skin lesions and the molecular pathways underlying the radiation signatures. Six stages of RT treatment were monitored from patients treated because of brain cancer: before starting the treatment, during the treatment (four time points), and at 4 weeks from the last RT dose. Serum samples w ...[more]

PMID: 31300526

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