Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos, LTQ Orbitrap Elite
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Lung, Epithelial Cell, Cell Culture
DISEASE(S): Influenza
SUBMITTER: Vicky Yang
LAB HEAD: Lienhard Schmitz
PROVIDER: PXD009634 | Pride | 2019-06-03
REPOSITORIES: Pride
Weber Axel A Dam Sharmistha S Saul Vera V VV Kuznetsova Irina I Müller Christin C Fritz-Wolf Karin K Becker Katja K Linne Uwe U Gu Hongbo H Stokes Matthew P MP Pleschka Stephan S Kracht Michael M Schmitz M Lienhard ML
Journal of virology 20190614 13
Influenza A viruses (IAVs) quickly adapt to new environments and are well known to cross species barriers. To reveal a molecular basis for these phenomena, we compared the Ser/Thr and Tyr phosphoproteomes of murine lung epithelial cells early and late after infection with mouse-adapted SC35M virus or its nonadapted SC35 counterpart. With this analysis we identified a large set of upregulated Ser/Thr phosphorylations common to both viral genotypes, while Tyr phosphorylations showed little overlap ...[more]