Proteomics

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Proteomics of prostate cancer patient derived xenografts

ABSTRACT: A set of 17 prostate cancer patient-derived xenografts (PDX, Lin et al 2014, Cancer research) was analyzed by mass spectrometry-based proteomics to characterize the effects of castration in vivo, and the proteome differences between NEPC and prostate adenocarcinomas.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Prostate Cancer Cell

DISEASE(S): Prostate Adenocarcinoma

SUBMITTER: Diego Iglesias-Gato  

LAB HEAD: Diego Iglesias-Gato

PROVIDER: PXD009636 | Pride | 2019-09-11

REPOSITORIES: Pride

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Publications

Proteogenomic Characterization of Patient-Derived Xenografts Highlights the Role of REST in Neuroendocrine Differentiation of Castration-Resistant Prostate Cancer.

Flores-Morales Amilcar A   Bergmann Tobias B TB   Lavallee Charlotte C   Batth Tanveer S TS   Lin Dong D   Lerdrup Mads M   Friis Stine S   Bartels Anette A   Kristensen Gitte G   Krzyzanowska Agnieszka A   Xue Hui H   Fazli Ladan L   Hansen Klaus H KH   Røder Martin A MA   Brasso Klaus K   Moreira José M JM   Bjartell Anders A   Wang Yuzhuo Y   Olsen Jesper V JV   Collins Colin C CC   Iglesias-Gato Diego D  

Clinical cancer research : an official journal of the American Association for Cancer Research 20181001 2

<h4>Purpose</h4>An increasing number of castration-resistant prostate cancer (CRPC) tumors exhibit neuroendocrine (NE) features. NE prostate cancer (NEPC) has poor prognosis, and its development is poorly understood.<b>Experimental Design:</b> We applied mass spectrometry-based proteomics to a unique set of 17 prostate cancer patient-derived xenografts (PDX) to characterize the effects of castration <i>in vivo</i>, and the proteome differences between NEPC and prostate adenocarcinomas. Genome-wi  ...[more]

PMID: 30274982

Publication: 1/2

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