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Proteomic analysis of Plasmodium yoelii oocyst sporozoites

ABSTRACT: Proteomic analysis of Plasmodium yoelii oocyst sporozoites

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Plasmodium Yoelii Yoelii 17xnl

DISEASE(S): Malaria

SUBMITTER: Kristian Swearingen

LAB HEAD: Robert L. Moritz

PROVIDER: PXD009729 | Pride | 2019-10-02

REPOSITORIES: Pride

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Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites.

Lindner Scott E SE Swearingen Kristian E KE Shears Melanie J MJ Walker Michael P MP Vrana Erin N EN Hart Kevin J KJ Minns Allen M AM Sinnis Photini P Moritz Robert L RL Kappe Stefan H I SHI

Nature communications 20191031 1

Plasmodium sporozoites are transmitted from infected mosquitoes to mammals, and must navigate the host skin and vasculature to infect the liver. This journey requires distinct proteomes. Here, we report the dynamic transcriptomes and proteomes of both oocyst sporozoites and salivary gland sporozoites in both rodent-infectious Plasmodium yoelii parasites and human-infectious Plasmodium falciparum parasites. The data robustly define mRNAs and proteins that are upregulated in oocyst sporozoites (UO ...[more]

PMID: 31673027

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