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The effect of bile acids on human placental proteome

ABSTRACT: The effects of bile acids on human placental proteome was examined

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Placenta

SUBMITTER: Antigoni Manousopoulou

LAB HEAD: Spiros D Garbis

PROVIDER: PXD009825 | Pride | 2019-11-14

REPOSITORIES: Pride

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Ursodeoxycholic acid inhibits uptake and vasoconstrictor effects of taurocholate in human placenta.

Lofthouse Emma M EM Torrens Christopher C Manousopoulou Antigoni A Nahar Monica M Cleal Jane K JK O'Kelly Ita M IM Sengers Bram G BG Garbis Spiros D SD Lewis Rohan M RM

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20190328 7

Intrahepatic cholestasis of pregnancy (ICP) causes increased transfer of maternal bile acids to the fetus and an increased incidence of sudden fetal death. Treatment includes ursodeoxycholic acid (UDCA), but it is not clear if UDCA protects the fetus. This study explores the placental transport of the bile acid taurocholate (TC) by the organic anion-transporting polypeptide, (OATP)4A1, its effects on the placental proteome and vascular function, and how these are modified by UDCA. Various method ...[more]

PMID: 30922127

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