Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Dominik Cysewski
LAB HEAD: Andrzej Dziembowski
PROVIDER: PXD009826 | Pride | 2018-07-06
REPOSITORIES: Pride
Pietras Zbigniew Z Wojcik Magdalena A MA Borowski Lukasz S LS Szewczyk Maciej M Kulinski Tomasz M TM Cysewski Dominik D Stepien Piotr P PP Dziembowski Andrzej A Szczesny Roman J RJ
Nature communications 20180702 1
The GC skew in vertebrate mitochondrial genomes results in synthesis of RNAs that are prone to form G-quadruplexes (G4s). Such RNAs, although mostly non-coding, are transcribed at high rates and are degraded by an unknown mechanism. Here we describe a dedicated mechanism of degradation of G4-containing RNAs, which is based on cooperation between mitochondrial degradosome and quasi-RNA recognition motif (qRRM) protein GRSF1. This cooperation prevents accumulation of G4-containing transcripts in h ...[more]