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Impacts of HLA-B57 micropolymorphism (MRM)

ABSTRACT: Comparison of peptide ligands of major histocompatibility class (MHC) I isolated by immunoaffinity purification from the C1R (Class I reduced) B-lymphoblastoid cell line, transfected with the MHC class I alleles HLA-B*57:01, HLA-B*57:03 and HLA-B*58:01.

INSTRUMENT(S): Q TRAP

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Suspension Culture

SUBMITTER: Patricia Illing

LAB HEAD: Anthony W. Purcell

PROVIDER: PXD009850 | Pride | 2018-10-24

REPOSITORIES: Pride

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HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome.

Illing Patricia T PT Pymm Phillip P Croft Nathan P NP Hilton Hugo G HG Jojic Vladimir V Han Alex S AS Mendoza Juan L JL Mifsud Nicole A NA Dudek Nadine L NL McCluskey James J Parham Peter P Rossjohn Jamie J Vivian Julian P JP Purcell Anthony W AW

Nature communications 20181108 1

Immunophenotypic differences between closely related human leukocyte antigen (HLA) alleles have been associated with divergent clinical outcomes in infection, autoimmunity, transplantation and drug hypersensitivity. Here we explore the impact of micropolymorphism on peptide antigen presentation by three closely related HLA molecules, HLA-B*57:01, HLA-B*57:03 and HLA-B*58:01, that are differentially associated with the HIV elite controller phenotype and adverse drug reactions. For each allotype, ...[more]

PMID: 30410026

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LFQ data for: Direct quantification of viral epitope abundance reveals the importance of direct and cross-presentation in driving CTL responses during influenza infection

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